Livedoid vasculitis - Vasculitis Livedoid
Is e galar cronail a th’ ann an Vasculitis Livedoid (Livedoid vasculitis) a chithear sa mhòr-chuid ann am boireannaich òga is meadhan-aois. Is e aon acronaim a thathar a’ cleachdadh airson cunntas a thoirt air na feartan aige, “Ualaran purpurach pianail le pàtran reticular de na h-àiteachan as ìsle” (PURPLE). Tha e co-cheangailte ri grunn ghalaran, a 'gabhail a-steach bruthadh-fala àrd venous agus varicosities.
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References
Is e suidheachadh craiceann tearc a th’ ann an Livedoid vasculopathy air a chomharrachadh le ulcers goirt a chumas a’ tilleadh air ais air na casan as ìsle.
Livedoid vasculopathy (LV) is a rare thrombotic vasculopathy of the dermis characterized by painful, relapsing ulcers over the lower extremities. Diagnosis is challenging due to the overlap in clinical appearance and nomenclature with other skin disorders. Treatment selection is complicated by poor understanding of the pathogenesis of LV and lack of robust clinical trials evaluating therapy efficacy. The terminology and pathophysiology of LV are reviewed here, along with its epidemiology, clinical and histologic features, and treatment options. A diagnostic pathway is suggested to guide providers in evaluating for comorbidities, referring to appropriate specialists, and choosing from the available classes of therapy.
Livedoid vasculopathy (LV) is a rare thrombotic vasculopathy of the dermis characterized by painful, relapsing ulcers over the lower extremities. Diagnosis is challenging due to the overlap in clinical appearance and nomenclature with other skin disorders. Treatment selection is complicated by poor understanding of the pathogenesis of LV and lack of robust clinical trials evaluating therapy efficacy. The terminology and pathophysiology of LV are reviewed here, along with its epidemiology, clinical and histologic features, and treatment options. A diagnostic pathway is suggested to guide providers in evaluating for comorbidities, referring to appropriate specialists, and choosing from the available classes of therapy.
Is e suidheachadh craiceann tearc a th’ ann an Livedoid vasculopathy a dh’ adhbhraicheas ulcers ath-chuairteachaidh air na casan ìosal, a’ fàgail sgarfaichean bàn air an cùlaibh ris an canar atrophie blanche. Ged nach eil an dearbh adhbhar fhathast soilleir, thathas a’ creidsinn gur e barrachd dòrtadh fala (hypercoagulability) am prìomh fheart, le sèid a’ cluich pàirt àrd-sgoile. Am measg nam factaran a tha a’ cur ri clotting tha na leanas - deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin gene mutations, high levels of homocysteine. Ann am biopsies, tha an suidheachadh a 'sealltainn clots fala taobh a-staigh shoithichean, ballachan shoithichean a' tiormachadh, agus sgrìobadh. Tha làimhseachadh a’ toirt a-steach dòigh-obrach ioma-fhillte a tha ag amas air casg a chuir air clotan fala le cungaidhean-leigheis leithid drogaichean an-aghaidh platelet, tinnearan fala, agus leigheas fibrinolytic. Faodar diofar dhrogaichean a chleachdadh airson an t-suidheachadh craiceann seo - colchicine and hydroxychloroquine, vasodilators, immunosuppressants.
Livedoid vasculopathy is a rare skin condition that causes recurring ulcers on the lower legs, leaving behind pale scars known as atrophie blanche. While the exact cause is still unclear, it's believed that increased blood clotting (hypercoagulability) is the main factor, with inflammation playing a secondary role. Factors contributing to clotting include as follows - deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin gene mutations, high levels of homocysteine. In biopsies, the condition shows blood clots inside vessels, thickening of vessel walls, and scarring. Treatment involves a multi-pronged approach focusing on preventing blood clots with medications like anti-platelet drugs, blood thinners, and fibrinolytic therapy. Various drugs can be used for this skin condition - colchicine and hydroxychloroquine, vasodilators, immunosuppressants.
Livedoid vasculopathy is a rare skin condition that causes recurring ulcers on the lower legs, leaving behind pale scars known as atrophie blanche. While the exact cause is still unclear, it's believed that increased blood clotting (hypercoagulability) is the main factor, with inflammation playing a secondary role. Factors contributing to clotting include as follows - deficiencies in proteins C and S, genetic mutations like factor V Leiden, antithrombin III deficiency, prothrombin gene mutations, high levels of homocysteine. In biopsies, the condition shows blood clots inside vessels, thickening of vessel walls, and scarring. Treatment involves a multi-pronged approach focusing on preventing blood clots with medications like anti-platelet drugs, blood thinners, and fibrinolytic therapy. Various drugs can be used for this skin condition - colchicine and hydroxychloroquine, vasodilators, immunosuppressants.
Is e suidheachadh ainneamh a th’ ann an Livedoid vasculopathy far a bheil lotan a’ nochdadh air gach cas. Thathas den bheachd gu bheil cruthachadh clotan fala ann an soithichean-fala beaga bìodach air adhbhrachadh le barrachd clotting agus nas lugha de bhriseadh clot, còmhla ri milleadh air loidhne an t-soithich. Tha e nas cumanta ann am boireannaich, gu h-àraid eadar aois 15 agus 50. Tha e air a bhith èifeachdach a bhith a' sgur de smocadh, a' gabhail cùram do lotan, agus a' cleachdadh cungaidhean-leighis leithid fuilnearan agus drogaichean antiplatelet.
Livedoid vasculopathy is a rare vasculopathy that is typically characterized by bilateral lower limb lesions. Increased thrombotic activity and decreased fibrinolytic activity along with endothelial damage are believed to be the cause of thrombus formation in the capillary vasculature. It is 3 times more common in females than in males, especially in patients between the ages of 15 to 50 years. There is no definite first-line treatment, but general measures like smoking cessation, wound care, and pharmacological measures like anticoagulants and antiplatelets have shown good results.
Livedoid vasculopathy is a rare vasculopathy that is typically characterized by bilateral lower limb lesions. Increased thrombotic activity and decreased fibrinolytic activity along with endothelial damage are believed to be the cause of thrombus formation in the capillary vasculature. It is 3 times more common in females than in males, especially in patients between the ages of 15 to 50 years. There is no definite first-line treatment, but general measures like smoking cessation, wound care, and pharmacological measures like anticoagulants and antiplatelets have shown good results.
